Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-intrapariet+P-trans

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2089827	0.1112185	0.0741921
Weighted median	23	-0.0714501	0.0597561	0.2318149
Inverse variance weighted	23	-0.0567703	0.0446412	0.2034791
Simple mode	23	-0.0890925	0.1062771	0.4108760
Weighted mode	23	-0.0890925	0.0637908	0.1764553

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.28807	21	0.1956771
Inverse variance weighted	29.05534	22	0.1432876

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093459	0.0062858	0.1519258

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009452	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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