Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-interm-prim-Jensen

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1540029	0.0994468	0.1364185
Weighted median	23	-0.0950426	0.0545403	0.0814016
Inverse variance weighted	23	-0.0683295	0.0388631	0.0787121
Simple mode	23	-0.0572701	0.0783284	0.4724018
Weighted mode	23	-0.0805878	0.0653095	0.2302470

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.71117	21	0.881683
Inverse variance weighted	14.58713	22	0.879339

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052605	0.0056206	0.3599504

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005357	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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