Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1380998	0.1134797	0.2371212
Weighted median	23	-0.0775516	0.0585179	0.1850834
Inverse variance weighted	23	-0.0341140	0.0443364	0.4416349
Simple mode	23	-0.0522380	0.1010767	0.6104416
Weighted mode	23	-0.1090454	0.0754387	0.1624175

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.36814	21	0.1589975
Inverse variance weighted	28.65967	22	0.1548362

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0063847	0.0064136	0.3308283

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008918	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8