Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0909731	0.1129594	0.4296364
Weighted median	23	-0.0032911	0.0572314	0.9541431
Inverse variance weighted	23	0.0270089	0.0444291	0.5432470
Simple mode	23	0.1774952	0.1054404	0.1064423
Weighted mode	23	-0.0232223	0.0632288	0.7169239

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.11684	21	0.1670192
Inverse variance weighted	28.77938	22	0.1512682

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007244	0.0063842	0.269293

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008867	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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