Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-front-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0897400	0.0994061	0.3768917
Weighted median	23	0.0021808	0.0550168	0.9683805
Inverse variance weighted	23	0.0571238	0.0388453	0.1414146
Simple mode	23	0.0797235	0.0962333	0.4163187
Weighted mode	23	-0.0221711	0.0664599	0.7418387

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.78548	21	0.7815805
Inverse variance weighted	18.36161	22	0.6843461

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090174	0.0056182	0.1234208

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006219	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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