Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-collat-transv-post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0626801	0.1189792	0.6038427
Weighted median	23	-0.0319009	0.0574053	0.5784065
Inverse variance weighted	23	-0.0030597	0.0457443	0.9466715
Simple mode	23	-0.1290451	0.0928013	0.1782688
Weighted mode	23	-0.0438874	0.0659962	0.5129625

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.08388	21	0.0903154
Inverse variance weighted	30.50842	22	0.1066216

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036607	0.0067244	0.5919108

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009246	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8