Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-collat-transv-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0683329	0.1119065	0.5480006
Weighted median	23	-0.0106287	0.0608131	0.8612557
Inverse variance weighted	23	0.0418471	0.0427921	0.3281150
Simple mode	23	0.0063165	0.1020037	0.9511826
Weighted mode	23	-0.0002377	0.0718140	0.9973885

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.61397	21	0.1839987
Inverse variance weighted	26.69776	22	0.2229313

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016262	0.0063247	0.799587

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008442	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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