Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-circular-insula-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1373645	0.1453503	0.3553769
Weighted median	23	-0.0133224	0.0621037	0.8301427
Inverse variance weighted	23	-0.0982080	0.0556063	0.0773740
Simple mode	23	0.0626533	0.1059123	0.5601764
Weighted mode	23	-0.0168683	0.0722817	0.8176328

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.89912	21	0.0017855
Inverse variance weighted	45.08225	22	0.0025908

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024042	0.0082149	0.7726503

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015592	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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