Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-circular-insula-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0677314	0.1532549	0.6630414
Weighted median	23	-0.0438411	0.0623722	0.4821216
Inverse variance weighted	23	-0.0248601	0.0586395	0.6716034
Simple mode	23	-0.0308934	0.1229099	0.8038763
Weighted mode	23	-0.0139949	0.0809137	0.8642635

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.91587	21	0.0003748
Inverse variance weighted	50.13539	22	0.0005622

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0026323	0.0086616	0.7641931

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015315	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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