Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-circular-insula-ant

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0493294	0.1340498	0.7165618
Weighted median	23	0.0234827	0.0604050	0.6974573
Inverse variance weighted	23	-0.0557161	0.0511822	0.2763376
Simple mode	23	0.0673113	0.1382431	0.6311413
Weighted mode	23	0.0372910	0.0856646	0.6675757

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.18789	21	0.0122504
Inverse variance weighted	38.19276	22	0.0174300

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003921	0.0075762	0.959209

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012197	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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