Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-cingul-Marginalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1146354	0.1058232	0.2909691
Weighted median	23	-0.0859936	0.0600887	0.1523983
Inverse variance weighted	23	-0.0230133	0.0412448	0.5768664
Simple mode	23	-0.1392073	0.1308351	0.2988724
Weighted mode	23	-0.1565946	0.1204490	0.2070266

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.79973	21	0.3028632
Inverse variance weighted	24.80240	22	0.3066174

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056256	0.0059809	0.3576072

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007622	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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