Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-central

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2396810	0.1015564	0.0280247
Weighted median	23	-0.1443368	0.0563074	0.0103660
Inverse variance weighted	23	-0.1026329	0.0407093	0.0116982
Simple mode	23	-0.1725794	0.1056611	0.1166311
Weighted mode	23	-0.1522017	0.0726241	0.0478297

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.91901	21	0.4041902
Inverse variance weighted	24.16237	22	0.3387764

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084148	0.0057398	0.1574494

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009437	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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