Two sample MR report

Telomere_length against aparc-a2009s lh thickness S-calcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2825723	0.1104477	0.0183048
Weighted median	23	-0.0934693	0.0593505	0.1152865
Inverse variance weighted	23	-0.0811426	0.0459407	0.0773545
Simple mode	23	-0.2433121	0.1031878	0.0276811
Weighted mode	23	-0.1365459	0.0703266	0.0651010

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.92564	21	0.2092984
Inverse variance weighted	30.77195	22	0.1008772

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0123679	0.0062423	0.060802

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010647	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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