Two sample MR report

Telomere_length against aparc-a2009s lh thickness Pole-temporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0859612	0.1105709	0.4455752
Weighted median	23	0.0128566	0.0591417	0.8279076
Inverse variance weighted	23	0.0018380	0.0429563	0.9658713
Simple mode	23	0.0594127	0.0972857	0.5476544
Weighted mode	23	-0.0100679	0.0639607	0.8763589

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.98153	21	0.2071541
Inverse variance weighted	26.90221	22	0.2149641

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0053909	0.0062492	0.3980775

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008153	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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