Two sample MR report

Telomere_length against aparc-a2009s lh thickness Pole-occipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2703254	0.0994044	0.0128433
Weighted median	23	-0.1380631	0.0549719	0.0120212
Inverse variance weighted	23	-0.1270798	0.0398966	0.0014464
Simple mode	23	-0.0770697	0.0879500	0.3903402
Weighted mode	23	-0.1274254	0.0673737	0.0718211

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.75665	21	0.4738895
Inverse variance weighted	23.20749	22	0.3900935

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0087953	0.0056182	0.132407

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010275	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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