Two sample MR report

Telomere_length against aparc-a2009s lh thickness Lat-Fis-post

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0499958	0.1158949	0.6705820
Weighted median	23	0.0212788	0.0564119	0.7060214
Inverse variance weighted	23	-0.0255070	0.0443029	0.5647893
Simple mode	23	0.0397480	0.0932666	0.6741204
Weighted mode	23	0.0211425	0.0616833	0.7350327

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.54436	21	0.1253771
Inverse variance weighted	28.61599	22	0.1561545

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015036	0.0065501	0.8206598

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008802	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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