Two sample MR report

Telomere_length against aparc-a2009s lh thickness Lat-Fis-ant-Vertical

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0990110	0.1134230	0.3925707
Weighted median	23	0.0211830	0.0550921	0.7006069
Inverse variance weighted	23	0.0154290	0.0445254	0.7289519
Simple mode	23	0.0061973	0.1002117	0.9512470
Weighted mode	23	-0.0334793	0.0652856	0.6131934

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.33917	21	0.1599067
Inverse variance weighted	28.90334	22	0.1476413

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070266	0.0064104	0.2854367

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008806	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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