Two sample MR report

Telomere_length against aparc-a2009s lh thickness Lat-Fis-ant-Horizont

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0960549	0.1076668	0.3824221
Weighted median	23	0.0069013	0.0578948	0.9051143
Inverse variance weighted	23	0.0443345	0.0430261	0.3028184
Simple mode	23	-0.0100928	0.1020040	0.9220779
Weighted mode	23	-0.0188885	0.0690459	0.7869713

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.63113	21	0.2634935
Inverse variance weighted	26.98475	22	0.2118061

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086201	0.0060852	0.1712743

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008572	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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