Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-temp-sup-Plan-tempo

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1579871	0.1137859	0.1795506
Weighted median	23	-0.0658071	0.0602652	0.2748514
Inverse variance weighted	23	-0.0803024	0.0440078	0.0680414
Simple mode	23	-0.0722602	0.1076255	0.5089519
Weighted mode	23	-0.0645292	0.0796724	0.4266536

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.51596	21	0.1544205
Inverse variance weighted	28.23677	22	0.1679664

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0047698	0.0064309	0.4664826

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009851	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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