Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-temp-sup-Plan-polar

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0252427	0.0994059	0.8020150
Weighted median	23	-0.0132359	0.0592728	0.8232979
Inverse variance weighted	23	-0.0384598	0.0388452	0.3221353
Simple mode	23	-0.0010863	0.1007359	0.9914934
Weighted mode	23	-0.0280402	0.0822054	0.7362654

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.55619	21	0.5495070
Inverse variance weighted	19.57706	22	0.6094771

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008115	0.0056182	0.886525

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006229	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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