Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-temp-sup-Lateral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1216508	0.1126617	0.2924825
Weighted median	23	-0.0636063	0.0622077	0.3065525
Inverse variance weighted	23	-0.0681242	0.0432852	0.1155230
Simple mode	23	0.0453665	0.1073112	0.6765768
Weighted mode	23	0.0205031	0.0789744	0.7975736

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.97462	21	0.1716948
Inverse variance weighted	27.31683	22	0.1994394

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032865	0.0063674	0.6111421

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009209	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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