Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-temp-sup-G-T-transv

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1414527	0.1130773	0.2247152
Weighted median	23	-0.0466965	0.0553234	0.3986328
Inverse variance weighted	23	-0.0623208	0.0437620	0.1544219
Simple mode	23	-0.0699466	0.0928053	0.4590249
Weighted mode	23	-0.0595930	0.0598678	0.3303601

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.17355	21	0.1651821
Inverse variance weighted	27.92146	22	0.1782988

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048586	0.0063908	0.455554

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009241	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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