Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-temporal-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0473929	0.1184670	0.6931590
Weighted median	23	0.0350276	0.0567176	0.5368528
Inverse variance weighted	23	0.0209818	0.0456508	0.6457930
Simple mode	23	0.0923956	0.0951763	0.3422092
Weighted mode	23	0.0721227	0.0685937	0.3044661

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.82570	21	0.0955468
Inverse variance weighted	30.38409	22	0.1094240

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041982	0.0066955	0.5374056

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009295	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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