Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1980914	0.1557651	0.2173729
Weighted median	23	-0.0398467	0.0597946	0.5051597
Inverse variance weighted	23	-0.1054372	0.0600576	0.0791565
Simple mode	23	-0.0544838	0.0878611	0.5415540
Weighted mode	23	-0.0150234	0.0668345	0.8242214

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.56424	21	0.0002201
Inverse variance weighted	52.58961	22	0.0002590

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056889	0.0088035	0.52514

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018164	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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