Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-subcallosal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0678958	0.1072147	0.5333944
Weighted median	23	-0.0296498	0.0599502	0.6209007
Inverse variance weighted	23	-0.0520879	0.0409589	0.2034756
Simple mode	23	0.0063384	0.0986193	0.9493348
Weighted mode	23	-0.0303780	0.0674540	0.6568635

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.42762	21	0.2728035
Inverse variance weighted	24.45747	22	0.3237149

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009706	0.0060596	0.8742711

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007956	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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