Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-rectus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0199492	0.1071207	0.8540505
Weighted median	23	0.0039080	0.0578751	0.9461642
Inverse variance weighted	23	0.0262767	0.0411112	0.5227172
Simple mode	23	0.0204279	0.0997721	0.8396534
Weighted mode	23	0.0094071	0.0717147	0.8968303

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.38528	21	0.2747676
Inverse variance weighted	24.64049	22	0.3145739

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028383	0.0060543	0.6440367

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007605	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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