Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2663173	0.1223584	0.0410719
Weighted median	23	-0.1309235	0.0561335	0.0196818
Inverse variance weighted	23	-0.0913072	0.0493279	0.0641659
Simple mode	23	-0.1326094	0.0992693	0.1952524
Weighted mode	23	-0.1407587	0.0614221	0.0318649

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.81853	21	0.0610730
Inverse variance weighted	35.47688	22	0.0345212

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0107457	0.0069155	0.1351596

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012424	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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