Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1801801	0.1019091	0.0915801
Weighted median	23	-0.1438829	0.0564151	0.0107589
Inverse variance weighted	23	-0.1058054	0.0394861	0.0073720
Simple mode	23	-0.1412755	0.0893809	0.1282407
Weighted mode	23	-0.1286448	0.0687268	0.0745859

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.0716	21	0.3953942
Inverse variance weighted	22.7323	22	0.4169753

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045666	0.0057597	0.4367267

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009136	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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