Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2548262	0.0994051	0.0181031
Weighted median	23	-0.1190947	0.0560194	0.0335070
Inverse variance weighted	23	-0.0891536	0.0391627	0.0228165
Simple mode	23	-0.1608475	0.0907225	0.0900824
Weighted mode	23	-0.1387396	0.0578658	0.0254264

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.08309	21	0.5798102
Inverse variance weighted	22.36139	22	0.4385037

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0101723	0.0056181	0.084534

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008372	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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