Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-pariet-inf-Supramar

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1890237	0.0994051	0.0710391
Weighted median	23	-0.0951214	0.0544261	0.0805129
Inverse variance weighted	23	-0.0735113	0.0388452	0.0584357
Simple mode	23	-0.0701057	0.0869648	0.4287914
Weighted mode	23	-0.0909975	0.0665250	0.1851640

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.16798	21	0.8144298
Inverse variance weighted	16.76168	22	0.7763745

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070925	0.0056182	0.2206383

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006165	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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