Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1829720	0.1078811	0.1046519
Weighted median	23	-0.1218740	0.0589953	0.0388449
Inverse variance weighted	23	-0.0760422	0.0423099	0.0722935
Simple mode	23	-0.1694994	0.1079098	0.1305128
Weighted mode	23	-0.1147421	0.0725529	0.1280360

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.73308	21	0.2589098
Inverse variance weighted	26.09870	22	0.2474684

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065655	0.0060972	0.2937833

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000907	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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