Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-oc-temp-med-Parahip

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0818693	0.0994068	0.4194340
Weighted median	23	-0.0026194	0.0542594	0.9614972
Inverse variance weighted	23	-0.0494273	0.0388453	0.2032260
Simple mode	23	0.0393191	0.0863268	0.6532360
Weighted mode	23	0.0057341	0.0651200	0.9306299

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.65205	21	0.4803617
Inverse variance weighted	20.77775	22	0.5345074

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019919	0.0056182	0.7264647

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006786	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8