Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-oc-temp-med-Lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1986016	0.1173059	0.1052353
Weighted median	23	-0.0395794	0.0558927	0.4788636
Inverse variance weighted	23	-0.0422719	0.0469681	0.3681130
Simple mode	23	-0.0272564	0.0941682	0.7749520
Weighted mode	23	-0.0408335	0.0577624	0.4870358

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.24343	21	0.1082789
Inverse variance weighted	32.16231	22	0.0746706

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0095985	0.0066298	0.1624431

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010105	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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