Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-oc-temp-lat-fusifor

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0507972	0.1158975	0.6656484
Weighted median	23	-0.0396813	0.0593206	0.5035404
Inverse variance weighted	23	-0.0533626	0.0442493	0.2278353
Simple mode	23	-0.0648002	0.0958167	0.5059026
Weighted mode	23	-0.0406920	0.0695292	0.5643347

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.54639	21	0.1253246
Inverse variance weighted	28.54717	22	0.1582488

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001575	0.0065503	0.9810425

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009222	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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