Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-occipital-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2967090	0.0994014	0.0070602
Weighted median	23	-0.1005382	0.0567356	0.0763867
Inverse variance weighted	23	-0.0985696	0.0388443	0.0111630
Simple mode	23	-0.1266065	0.0982329	0.2108421
Weighted mode	23	-0.1187717	0.0801838	0.1527234

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.47377	21	0.7424692
Inverse variance weighted	21.16326	22	0.5106690

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.012166	0.0056181	0.0420079

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008363	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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