Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-occipital-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1887393	0.1114407	0.1051182
Weighted median	23	-0.0804876	0.0591102	0.1733077
Inverse variance weighted	23	-0.1039238	0.0432339	0.0162276
Simple mode	23	0.0449977	0.1100099	0.6864698
Weighted mode	23	-0.0572770	0.0786689	0.4742453

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.39332	21	0.1918471
Inverse variance weighted	27.25254	22	0.2017915

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052077	0.0062984	0.4176321

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010426	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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