Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-insular-short

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0406339	0.1100772	0.7157194
Weighted median	23	-0.0093202	0.0568227	0.8697133
Inverse variance weighted	23	-0.0469283	0.0420301	0.2641907
Simple mode	23	-0.0770892	0.1027039	0.4608488
Weighted mode	23	-0.0125110	0.0654009	0.8500470

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.75031	21	0.2161299
Inverse variance weighted	25.75505	22	0.2623476

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003865	0.0062213	0.9510536

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008247	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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