Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-front-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2286283	0.1283166	0.0892579
Weighted median	23	-0.0110764	0.0614243	0.8568964
Inverse variance weighted	23	-0.0760300	0.0509005	0.1352545
Simple mode	23	-0.0481688	0.1034660	0.6461124
Weighted mode	23	-0.0063693	0.0896745	0.9440182

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.99434	21	0.0282755
Inverse variance weighted	37.77585	22	0.0194114

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093696	0.0072522	0.2104073

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012606	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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