Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-front-middle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1363846	0.0994057	0.1845434
Weighted median	23	-0.0564781	0.0526936	0.2838005
Inverse variance weighted	23	-0.0541847	0.0388453	0.1630509
Simple mode	23	-0.0839375	0.0830988	0.3234318
Weighted mode	23	-0.0809404	0.0634219	0.2151862

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.10894	21	0.6421004
Inverse variance weighted	18.91596	22	0.6505121

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050471	0.0056182	0.3791867

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006321	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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