Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-front-inf-Triangul

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1304204	0.0994064	0.2036843
Weighted median	23	-0.0677399	0.0561126	0.2273499
Inverse variance weighted	23	-0.0257297	0.0388454	0.5077401
Simple mode	23	-0.0677464	0.0963735	0.4894555
Weighted mode	23	-0.0651183	0.0684938	0.3520758

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.83685	21	0.7209477
Inverse variance weighted	18.14589	22	0.6973045

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.006428	0.0056182	0.2654428

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005632	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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