Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-front-inf-Orbital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1332853	0.1134978	0.2534034
Weighted median	23	-0.1156704	0.0608470	0.0573015
Inverse variance weighted	23	-0.0368942	0.0442022	0.4039038
Simple mode	23	0.1371821	0.1310370	0.3065142
Weighted mode	23	-0.1595528	0.0748954	0.0445698

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.37661	21	0.1587324
Inverse variance weighted	28.48636	22	0.1601176

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059185	0.0064148	0.366674

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008905	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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