Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-front-inf-Opercular

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1565013	0.1048995	0.1505918
Weighted median	23	-0.1039293	0.0609050	0.0879304
Inverse variance weighted	23	-0.0523956	0.0411435	0.2028455
Simple mode	23	-0.1966247	0.1099916	0.0876202
Weighted mode	23	-0.1478788	0.0845928	0.0943859

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.38597	21	0.3237497
Inverse variance weighted	24.68047	22	0.3125976

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0063921	0.0059287	0.2931905

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000803	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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