Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1775874	0.1099736	0.1212759
Weighted median	23	-0.0524246	0.0555297	0.3451277
Inverse variance weighted	23	-0.0508825	0.0435248	0.2423854
Simple mode	23	-0.0962573	0.0881283	0.2865444
Weighted mode	23	-0.0520088	0.0595846	0.3921697

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.70221	21	0.2180321
Inverse variance weighted	27.61967	22	0.1886304

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077796	0.0062154	0.2244558

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008889	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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