Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-cingul-Post-ventral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0038596	0.1207481	0.9748026
Weighted median	23	-0.0371355	0.0599241	0.5354494
Inverse variance weighted	23	-0.0102216	0.0461048	0.8245442
Simple mode	23	-0.0632914	0.1216443	0.6080522
Weighted mode	23	0.0262425	0.0790493	0.7430489

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.98338	21	0.0739349
Inverse variance weighted	30.98822	22	0.0963569

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003906	0.0068244	0.9548952

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009411	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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