Two sample MR report

Telomere_length against aparc-a2009s lh thickness G-cingul-Post-dorsal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0575496	0.0994088	0.5688026
Weighted median	23	0.0172937	0.0549240	0.7528636
Inverse variance weighted	23	0.0078448	0.0388465	0.8399606
Simple mode	23	0.0762736	0.0905994	0.4089152
Weighted mode	23	0.0318402	0.0657990	0.6332385

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.75565	21	0.4739510
Inverse variance weighted	21.26639	22	0.5043312

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040152	0.0056184	0.48269

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006457	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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