Two sample MR report

Telomere_length against aparc-a2009s lh thickness G+S-transv-frontopol

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0653348	0.1140686	0.5728845
Weighted median	23	0.0045472	0.0546143	0.9336443
Inverse variance weighted	23	0.0218649	0.0442596	0.6212958
Simple mode	23	0.0285912	0.0818717	0.7302447
Weighted mode	23	-0.0002497	0.0578077	0.9965920

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.65198	21	0.1503003
Inverse variance weighted	28.56016	22	0.1578519

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005354	0.0064468	0.4156075

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000875	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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