Two sample MR report

Telomere_length against aparc-a2009s lh thickness G+S-subcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1191935	0.1035528	0.2626533
Weighted median	23	-0.0452074	0.0577532	0.4337628
Inverse variance weighted	23	-0.0643311	0.0398458	0.1064180
Simple mode	23	-0.2078221	0.0956416	0.0408326
Weighted mode	23	-0.0600196	0.0702870	0.4023513

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.78845	21	0.3553607
Inverse variance weighted	23.14794	22	0.3934166

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033685	0.0058526	0.5710258

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007845	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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