Two sample MR report

Telomere_length against aparc-a2009s lh thickness G+S-paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2325962	0.1116943	0.0497172
Weighted median	23	-0.0785165	0.0575703	0.1726194
Inverse variance weighted	23	-0.0737234	0.0450030	0.1013826
Simple mode	23	-0.1076900	0.1045202	0.3140511
Weighted mode	23	-0.0969983	0.0716841	0.1897544

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.51364	21	0.1875372
Inverse variance weighted	29.52839	22	0.1303844

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0097548	0.0063127	0.1372212

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010039	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8