Two sample MR report

Telomere_length against aparc-a2009s lh thickness G+S-occipital-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1232116	0.1023112	0.2418789
Weighted median	23	-0.0127687	0.0593096	0.8295424
Inverse variance weighted	23	-0.0626299	0.0394446	0.1123330
Simple mode	23	-0.0187938	0.1127155	0.8691002
Weighted mode	23	-0.0094802	0.0850467	0.9122542

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.24607	21	0.3854508
Inverse variance weighted	22.68444	22	0.4197277

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037197	0.0057824	0.527004

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007661	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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