Two sample MR report

Telomere_length against aparc-a2009s lh thickness G+S-frontomargin

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1576158	0.1021271	0.1376869
Weighted median	23	-0.0059863	0.0582283	0.9181161
Inverse variance weighted	23	0.0163720	0.0410334	0.6898990
Simple mode	23	-0.0795197	0.1046974	0.4556043
Weighted mode	23	-0.0076564	0.0705688	0.9145860

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.16570	21	0.3900156
Inverse variance weighted	24.54848	22	0.3191497

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086724	0.005772	0.1478603

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007492	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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